Noyes dating endometrium
To ensure a maximum amount of tissue for morphological reading, the specimen should be placed on a piece of lens paper or some other adhesive tissue and then immersed in the fixative.
By this means, all of the tissue fragments remain tightly attached to the lens paper, rather than floating in the fixative, and no tissue will be lost for histologic examination.
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Morphologically, the endometrium is one of the most dynamic target tissues in women.
Its cyclic structural changes mirror changes in metabolic functions, and both are regulated by ovarian estradiol and progesterone. Schematic representation of steroid hormone-morphologic interactions during the endometrial cycle.
Method To ensure a good specimen for morphologic interpretation, a biopsy sample should be taken from both the anterior and the posterior endometrium and fixed immediately in 10% buffered formalin.
In current practice, the device that is most often used is the Pipelle endometrial aspirator.